Jaundice due to carbimazole.

Cholestatic jaundice following carbimazole therapy in an elderly thyrotoxic patient.

Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis.

A 36-year-old Chinese man presented to the Queen Mary Hospital in August 1999 with a 2-week history of jaundice due to propylthiouracil treatment for thyrotoxicosis. He had previously received carbimazole but had developed an urticarial skin rash after 2 weeks of treatment. The patient developed liver failure and fulminant pneumonitis shortly after hospital admission. Despite receiving treatmen...

Thyroid storm presenting as jaundice and complete heart block.

Thyroid storm is a difficult diagnosis in "apathetic" variant of hyperthyroidism. The clinical features may not be evident. Abnormal atrioventricular (AV) conduction, such as complete heart block, in thyrotoxicosis is uncommon. We report a case of a 16-year-old girl presenting with fever, jaundice, heart failure and complete heart block in whom the diagnosis of thyroid storm was initially misse...

Effect of Selenium on Carbimazole-Induced Histopathological and Histochemical Alterations in Prostate of Albino Rats

Carbimazole is an antithyroid drug used in treatment of hyperthyroidism. The present study is undertaken to evaluate the effect of carbimazole in prostate of albino rats and the ameliorative role of selenium. Treating rats with carbimazole(1.35mg/Kg b.w) daily for 8 weeks caused distinct histological alterations in prostate gland compared with control group. The epithelial cells of prostatic ac...

A 40-Year-Old Woman Who Developed Jaundice during Therapy for Thyrotoxicosis

A 40-year-old woman presented to a tertiary-care facility on the 11th of October 2004, having been referred from a private-health clinic for continued treatment of thyrotoxicosis. The referring doctor had started her on carbimazole, 60 mg daily 11 months earlier. She discontinued treatment after three months for fi nancial reasons. She was referred to the state tertiary facility because the fee...